Ketamine therapy

Why do we treat with ketamine?

Confirmed safety

Ketamine is a drug commonly used in pediatric and adult anaesthesiology, in dentistry, and for pain control. Its safety for humans is confirmed.

Treatment effectiveness up to 70%

The efficacy of ketamine in the treatment of depression is documented by many scientific studies. In 30–70 % of treated patients it takes effect within one week of administration. In recent years, ketamine therapy has expanded to include other indications as well.

Rapid antidepressant effect

In up to half of the people who respond to ketamine therapy, the effect sets in on the day of administration and lasts about 3–10 days. The aim of ketamine-assisted psychotherapy is to substantially prolong the duration of this effect through psychotherapeutic work.

New hope for treatment-resistant disorders

KAT has been shown to work in people for whom previous treatments have proved to be less effective or completely without effect.

The Healing State of Expanded Consciousness

It provides insight into mental contents that are difficult to access in conventional therapy (e.g. unconscious processes, old memories, unmet needs, etc.) and assists in their processing and healing.

Wide range of treatment indications

In recent years, treatment has expanded to include indications other than depression: anxiety disorders, eating disorders, post-traumatic stress disorder and obsessive-compulsive disorder.

Ketamine is not just an anaesthetic

In psychiatric indications, ketamine is used in much lower doses that do not induce general anaesthesia or loss of consciousness. The effects of low-dose ketamine typically include:

  • subtle dream-like or dissociative state;
  • anxiolytic (anxiety relieving) effect;
  • antidepressant effect and reduced risk of suicide;
  • state of expanded consciousness, also known as a psychedelic experience.
Ketamine-assisted Psychotherapy

Pharmacological extension
of psychotherapy

Our method of working with ketamine is called ketamine-assisted psychotherapy. Ketamine-assisted psychotherapy combines the benefits of psychotherapeutic treatment with the pharmacological effects of ketamine, primarily its antidepressant and anxiolytic properties. The resulting synergy helps fully exploit the potential of ketamine and, conversely, significantly enhances the psychotherapeutic process. Ketamine-assisted psychotherapy is therefore pharmacologically assisted psychotherapy, i.e. an extension of psychotherapy. As such, it is suitable for a wide range of mental health problems.

We know from experience that even for clients who are already in long-term psychotherapy, ketamine-assisted psychotherapy can lead to significant insights and breakthroughs that they can use in their future psychotherapeutic work.

The Healing State of Expanded Consciousness
During treatment, the client often comes into contact with a range of emotions and memories that are more difficult to access in a normal state of consciousness. This experience, set in the framework of systematic psychotherapy and carefully integrated into daily life, is an ideal means of deepening the healing process of the client and making it more effective.
prof. MUDr. Jiří Horáček, Ph.D., FCMA
Founder of PSYON, Physician, Educator, Deputy for Science and Research at National Institute of Mental Health

State of expanded consciousness
fosters long-term change

In contrast to conventional psychotherapy, ketamine allows the client to experience an expanded consciousness – a state of altered perception, thought and experience. According to a growing body of scientific research, this state allows insight into the dysfunctional psychological mechanisms underlying mental illness and their gradual change.

It provides insight into mental contents that are difficult to access in conventional therapy (e.g. unconscious processes, old memories, unmet needs, etc.) and assists in their processing and healing. In other words, it helps us discover who we really are.

Ketamine-assisted psychotherapy is therefore an effective means of augmenting psychotherapy and facilitating long-term change, which is something ketamine alone usually cannot provide.

Effects of ketamine-assisted psychotherapy

New perspective on routine thinking and habitual patterns of thought and behavior
Significant changes in perception of self, relationships and one's place in the world
Positive outlook on difficult situations and challenges in life
Reduction in the frequency and intensity of negative or compulsive thoughts
Greater motivation to achieve desired changes in life
Increased self-esteem and self-compassion
Increased ability to deal with life's difficulties
Relief from existential anxiety and increased potential for greater interest in spirituality

What does the treatment help with?

In the field of mental health, ketamine is currently used as an off-label therapy. This means that the drug may be used for indications other than its primary purpose (in the Czech Republic, this is only general anesthesia and analgesia in the case of ketamine). Such use is regulated by law and is permitted on the basis of comprehensive scientific evidence for each individual indication.

This is in line with our focus on clients who have tried other treatments for their condition in the past (e.g. psychotherapy and/or pharmacotherapy).

Depression and depressive
spectrum disorders

Ketamine-assisted treatment can be effective even in cases of treatment-resistant depression.

Anxiety disorders
and OCD

These include social phobia, generalized anxiety disorder (GAD), obsessive-compulsive disorder (OCD) and others.

Post-traumatic stress disorder (PTSD)

Clients suffering from PTSD can also greatly benefit from ketamine-assisted treatment.

Mental anorexia and mental bulimia

Eating disorders are also something ketamine-assisted therapy can help with.

Jak probíhá

Ketamine-assisted therapy

The psychotherapeutic framework is an essential part of the treatment process in ketamine-assisted therapy. However, since the need for psychotherapy varies widely from person to person, we offer two different approaches to treatment:

Some clients derive the greatest benefit from therapeutic processing of the ketamine experience. For them, we use an approach in which the ketamine experience is preceded and followed by multiple therapy sessions.

Some clients benefit primarily from the pharmacological effects of ketamine. In these cases, we use an approach that involves multiple ketamine sessions.

The doctor will discuss these options and the results of the examinations in detail with the client, and together they will choose the most suitable treatment.

Full course of ketamine-assisted therapy

Detailed course of therapy



Initial online interview

25 min

The first step for anyone interested in ketamine-assisted therapy is an initial online appointment. During the call, we will discuss the client's expectations and answer any questions.



Comprehensive psychiatric evaluation

90-120 min
in person

Before starting ketamine-assisted therapy, each client must undergo a comprehensive psychiatric assessment by our psychiatrist.



Physical examination

30–60 minut
in person

To ensure that ketamine-assisted therapy is a safe choice for the client, a physical examination with blood sampling and heart tests (echocardiography or ECG) is required.



Ketamine-assisted therapy

8-14 hodin
in person

The ketamine-assisted treatment itself is a series of at least five sessions consisting of preparation sessions, ketamine session, and integration sessions.

Ketamine-Assisted Therapy in Numbers
scientific studies confirm the effectiveness of ketamine-assisted therapy
scientific studies confirm the safety of ketamine-assisted therapy
specialized facilities in the USA and several other institutions in Europe already provide ketamine-assisted treatment
77 %
of our clients feel a positive change at the end of the treatment

Team of world-class professionals

We are proud that our therapists are almost the only ones in the Czech Republic and among the select few hundred people worldwide to have completed official training in psychedelic-assisted psychotherapy, mostly from abroad. Some of the most important training programs include:

01 California Institute of Integral Studies: Psychedelic-Assisted Therapies and Research
02Compass Pathways: Compass Therapist (treatment of depression with psilocybin)
03Polaris Insight Center: Ketamine-Assisted Psychotherapy
04MAPS: MDMA-Assisted Psychotherapy for PTSD
05Stargate: Working With Non-Ordinary States of Consciousness

clients have already
undergone treatment


„I understand the meaning of what I saw, and now I can connect it to what troubled me.”

Julia Holaňová

„I felt that a change had been set in motion. I learned to let go of things and go with the flow.”


The most common concerns of our clients

You can never predict where the experience will go, so it cannot be completely controlled. What we can do, however, is build trust and create an environment where you feel safe and comfortable. And that is what the preparation sessions are for.

The strongest foundation is a sense of trust in the therapist. This is built up during the preparation phase, when the therapist and client get to know each other and the client gains experience interacting with the therapist. Together we create a safe space where everything is welcome and the client can relinquish at least some control over their behavior. Therapist and client also agree options and forms of support together in advance so that the client can venture into more challenging topics or feelings if the experience takes them there.

As part of the preparation, the therapist and client also discuss the external framework of the session, i.e. what we can control. This includes the proximity/distance of the therapist, the level of support and contact, etc. We make it clear that the therapist, who will be present throughout the session, and the physician, who will be available on site, will help keep the client safe at all times and ensure nothing happens to the client’s body, i.e. prevent falls and other injuries.

You may find the experience challenging. However, it is important to remember that while the experience may be challenging, it is not unmanageable. In fact, difficult psychedelic experiences are considered an important factor in the treatment of mental disorders. You can’t encounter anything you won’t be able to handle. In addition, you will have a therapist by your side to support you at all times. As part of the preparation, you will practice breathing techniques to help you manage anxiety and calm your mind.

Going through a challenging experience can sometimes help you move forward in therapy – this is also something to bear in mind. During integration, each experience is interpreted in the context of the client’s life and individual journey. The therapist helps the client process the experience in a way that allows the client to build on it and grow. Ketamine also has an anxiolytic (anxiety-relieving) effect, which makes it easier for the client to explore challenging feelings and touch on deeper issues and experiences without feeling overwhelmed.

Finally, it should be noted that difficult experiences among recreational users usually occur when they do not know what they are getting into, have no support, and are not in a safe environment. All of these aspects are addressed in the clinic.

The risk of addiction exists almost exclusively in people who use ketamine recreationally, very frequently, and in higher doses than in ketamine-assisted therapy.

Using ketamine in a therapeutic context is deep work that is subsequently integrated into one’s life. It is not a shortcut to pleasure, as is typically the case with recreational use. It is therefore not tempting to use it frequently.

Sometimes it takes only one ketamine experience for difficulties to subside or to diminish substantially. In other cases, however, the client, together with the therapist and the indicating psychiatrist, may come to the conclusion that a repetition of the treatment would be appropriate in order to reinforce, amplify or deepen the therapeutic effect. This option is of course available and is frequently used and recommended both in the Czech Republic and abroad (more about repeat therapy here).

We would like to emphasize that you should not make any demands on yourself in the sense that ketamine-assisted therapy is the only way to advance your therapeutic process. During therapy, we do everything we can to make one session of ketamine sufficient; however, if we come to the conclusion that a re-administration is advisable, it is neither the client’s fault nor a sign of ineffective treatment. Certain deep-rooted themes with origins in childhood often take more time to resolve. Sometimes, the journey is simply a little longer.

Don’t worry. The risk of developing a psychotic disorder after taking psychedelics in general is extremely low, unless there are contraindications to psychedelic therapy. Ketamine is no exception and is also considered safe in this regard. To ensure the highest level of safety, each patient must undergo a comprehensive evaluation process, including a risk assessment for the development of psychosis, before treatment can be indicated. Ketamine-assisted therapy is not suitable for individuals with a family history of psychotic disorders (e.g. schizophrenia). It is useful to bear in mind that the effect of ketamine has its own dynamic: It’s a return ticket – “there and back again” – and one always comes back to the “shared” reality.

Full price list
ketamine-assisted therapy

Are you interested in standard psychotherapeutic or psychiatric services, where we focus on the full spectrum of mental illnesses as a part of services fully covered by public health insurance? Take a look at the services of our outpatient psychiatric clinic and psychotherapy.

Type of Therapy
Select "Initial" if this is your first ketamine-assisted therapy with us. Select "Repeated" if you have already undergone ketamine-assisted therapy with us and are proceeding with continued treatment.
Number of Therapists
Typically, ketamine-assisted therapy is facilitated by one experienced therapist. There is also an option to have two therapists present. This model provides a deeper insight into issues through the eyes of two experienced therapists. If desired, for instance, it is possible to relate to both male and female perspectives. For some clients, the presence of two therapists may offer a sense of greater certainty and security, leading to increased comfort during the ketamine experience.
Language of Therapy
The entire process of ketamine-assisted therapy is also available in English. The services differ in price.

Vstupní terapie s 1 terapeutem

Ketaminem asistovaná terapie v českém jazyce
Treatment Step

Person insured by
Psyon has contracts with 6 insurance companies that fully cover standard outpatient services. For ketamine-assisted therapy, services are partially covered.



Customers of other insurance companies

10 700–13 700 Kč(3)

Kompletní cena léčby včetně DPH
Book an appointment

22 500–29 700 Kč(3)

Kompletní cena léčby včetně DPH
Book an appointment

Person insured by
Psyon has contracts with 6 insurance companies that fully cover standard outpatient services. For ketamine-assisted therapy, services are partially covered.


10 700–13 700 Kč(3)

Full Prices of Treatment (price include VAT)
Book an appointment


Customers of other insurance companies

10 700–13 700 Kč(3)

Full Prices of Treatment (price include VAT)
Book an appointment
(1) Not a medical procedure. (2) Some of the procedures, which are part of the ketamine-assisted therapy treatment, are not among those covered by medical insurance. (3) The final price depends on the particular form of treatment, which will be determined by the doctor in consultation with the client. (4) The examination is provided by Kardio-psyche s.r.o., which is located on the premises of the Psyon clinic. All prices include VAT and are for services provided in a foreign language Price list for Czech speaking clients

For those who cannot afford the treatment (e.g. people whose mental illness prevents them from earning an adequate income, people on disability pensions, students, retirees, etc.), we have a subsidy program. The goal of this program is to significantly reduce the price of our services so that they are as affordable as possible, which is our long-term goal. Please indicate your interest in the subsidy program during the initial online meeting. Learn more about the subsidy program.

Schedule an initial meeting

your time

All contacts

Complete Guide to Therapy

Go through the whole process of ketamine-assisted therapy in the comfort of your home. We have put together the most important information in our easy-to-read booklet.

Do you have a specific question?

Ask us whatever you want using our question form. We do our best to respond within 48 hours at most.

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